CBG and CBGA Research
CBG and CBGA
CBG, cannabigerol, is one of over 120 cannabinoids, which have been discovered within the Cannabis sativa plant. Cannabigerol (CBG) is a well-known non-psychoactive compound that is also known as the mother of all cannabinoids. It is present only 1% in cannabis plants. Cannabigerolic acid (CBGA) is an acidic form of CBG and precursor of all cannabinoids, including CBG. The enzymatic degradation of CBGA converts it into three cannabinoids; tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).
The main areas of research and recent discoveries on CBG and CBGA
Several medical and scientific research publications highlighted the pharmacology of CBG. The discovery that endocannabinoid receptors are not only present in the brain but also in other parts of the body such as bones, skeletal muscle, skin, fat tissue, immune cells, liver, pancreas, heart, blood vessels, gastrointestinal tract, and kidney gave rise to new areas of research. CBG acts as an agonist on G-protein-coupled receptors, i.e., CB1 and CB2 receptors. The study also found a stimulating effect of CBG on α2 adrenoceptors. However, it also act as an antagonist on TRPV8 receptors.
Modern-day research is more inclined toward finding the therapeutic benefits of CBG. The discovery of potential binding sites for CBG in the body opened a new window of therapeutic research on CBG. Currently available therapeutic data were obtained from animal studies. The finding of binding domains of endocannabinoids receptor and their modulation by CBG helped determine the purposed impact of these cannabinoids on different organs. For instance, the potent antagonist activity of CBG on TRPM8 can help combat prostate cancer, bladder pain, and detrusor overactivity.
CBG has more potential to block the lipoxygenase pathway than THC, thus produce a more significant analgesic and anti-inflammatory effect. An old research study performed in 1982 discovered the anti-fungal effect of CBG. Cannabigerol is also popular for its cytotoxic (anti-cancerous) product, which is exerted on human epithelioid carcinoma in high doses. A study performed in 2010 noted moderate 5-HT1A antagonist action of cannabigerol, which confirms the antidepressant and mild antihypertensive effect of CBG in the rodent tail suspension model.
Researchers are now engaged in identifying CBG as therapy for an array of ailments.
Application areas of CBG and CBGA
Advance research and its beneficial outcomes have widened CBG and CBGA application areas.
Despite the lack of human data, there is an upsurge in the consumer use of cannabigerol for health and wellbeing. Convincing testimonial from consumers raises the demand and popularity of CBG.
Application in the cosmetics industry
Acceptance of cannabigerol and its acidic precursor has increased in cosmetics. CBG is a vital skincare and cosmetics ingredient approved by the European Commission due to its antibacterial, anti-inflammatory, and antioxidant properties.
Application in Veterinary
Various preclinical studies highlighted the relaxing effect of CBG in animals without causing drowsiness. CBG holds a variety of health benefits for your canine friend. This may include enhancing brain function, producing an anti-emetic effect, supporting cellular, immune and normal urinary tract functions, reducing oxidative stress and discomfort.
Application in the Healthcare system
CBG also reduced the burden on the human healthcare system by positively impacting various ailments, including cancer, bladder dysfunction, glaucoma, Parkinson’s disease, Inflammatory bowel disease.
Application in the food industry
Due to the history of safe consumption of CBG in humans, it is possible to use this cannabinoid in the food industry. The manufacturer must send FDA a “new dietary ingredient notification” within 75 days of marketing the product.
The legality of CBG and CBGA
CBG and CBGA are not listed in controlled substances. CBG and CBGA derived from hemp are federally legal under Farm Bill 2018. However. the legality of manufacturing, possession, and consumption of CBG and CBGA may vary from state to state. Till February 2021, 47 states allowed CBG. 15 states legalized the recreational and adult use of CBG. Despite legalization, all the CBG products are closely observed by FDA.
The uniqueness of the Biomedican’s CBG and CBGA method of production
CBG is considered one of the most “high-end” cannabinoids because it is difficult to acquire and has many health benefits. Biomedican introduced organic biosynthesis to yield this high-end cannabinoid. The production of CBG/CBGA through biosynthesis offers a way to reduce the environmental footprint, decrease production time, circumvent regulatory oversight, and produce high-quality cannabinoids. Biomedican uses a unique proprietary yeast that undergoes the natural metabolic process of fermentation to make CBG/CBGA identical to its counterparts in nature. The advantage of this natural process is that it is 100% pure, reliable, and does not come with the undesirable side effects of chemical synthesis.
Links to research
Visit the following links to know more about recent studies on CBG and CBGA and the participation of Biomedican in the cannabis community.
- BIOMEDICAN Announces Successful Biosynthesis and Large-Scale Production of Rare Cannabinoids CBG/CBGA
- The Role of 5-HT1A Receptors, and Nausea and Vomiting Relief by Cannabidiol (CBD), Cannabidiolic Acid (CBDA), and Cannabigerol (CBG)
Frequently asked questions:
Are CBG products legal?
CBG and CBGA are not listed in controlled substances. CBG and CBGA derived from hemp are federally legal under Farm Bill 2018. However. The legality of manufacturing, possession, and consumption of CBG and CBGA may vary from state to state. Till February 2021, 47 states allowed CBG. 15 states legalized the recreational and adult use of CBG. Despite legalization, all the CBG products are closely observed by FDA.
Can you take too much CBG?
A common saying is, “The difference between a good medicine and a poison is the dosage.”
Therefore, CBG must be taken in an appropriate amount to receive its desired therapeutic effects.
How is CBG made?
Young cannabis plants have cannabigerolic acid (CBGA). Cannabigerolic acid (CBGA) is an acidic form of CBG and precursor of all cannabinoids, including CBG. CBGA undergoes enzymatic degradation and converts into three cannabinoids; tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). The resulting acidic forms of these cannabinoids produce THC and CBD by a decarboxylation reaction catalyzed by light or heat.
Is cannabigerol(CBG) psychoactive?
Unlike THC, CBG is non-psychoactive, which means it will not get you “high.”
What are the side effects of CBG?
There is not enough information from scientific evidence to know if cannabigerol is safe and what the side effects it may have.
However, Too much intake of CBG may cause diarrhea.
What is CBG oil?
CBG oil is extracted from cannabinoid -cannabigerol (CBG). Pure CBG oil is rare but much more beneficial compared to other cannabinoids. CBG is utilized due to its fat-burning, pain alleviating, and mood-stabilizing properties. It is also used to maintain the sleep cycle.
What is CBG used for?
Use in cosmetics products: CBG is a vital skincare and cosmetics ingredient approved by the European Commission due to its antibacterial, anti-inflammatory, and antioxidant properties.
Veterinary use: Various preclinical studies highlighted the relaxing effect of CBG in animals without causing drowsiness. CBG holds a variety of health benefits for your canine friend.
Use in the food industry: Due to the history of safe consumption of CBG in humans, it is possible to use this cannabinoid in the food industry.
CBG also reduced the burden on the human healthcare system by positively impacting various ailments. A few of the many promising health/medical benefits of CBG include treatment of:
- Huntington’s Disease – In several models of Huntington’s Disease, treatment with CBG has been shown to reduce the loss of brain cells and improve motor function.
- Multiple Sclerosis (MS) – In models of MS, CBG has been shown to alleviate symptoms by preventing the overactivation of immune cells.
- Parkinson’s Disease – In Parkinson’s, cells in the nigrostriatal region of the brain are lost. Studies have indicated that CBG may help to both prevent the destruction of and augment the recovery of brain cells in this region.
- Colon Cancer – Studies have demonstrated that extracts containing CBG have properties that may kill colon cancer cells.
- Appetite Stimulation – CBG may improve appetite by increasing how often hunger sets in, with minimal side effects.
What is CBG?
CBG, cannabigerol, is one of over 120 cannabinoids, which have been discovered within the Cannabis Sativa plant. Cannabigerol (CBG) is a well-known non-psychoactive compound known as the mother of all cannabinoids. It is present only 1% in cannabis plants.
What is CBGA good for?
There is limited medical research on CBGA. However, early studies have provided some suggestions about its potential applications.
Cardiovascular Disease: CBGA may help combat cardiovascular disease in diabetic patients. An in vitro study found CBGA as an inhibitor of enzyme aldose reductase. This enzyme leads to heart and other problems as a contributor of the oxidative stress.
Metabolic Disorders: CBGA may also treat patients with metabolic disorders. A simulation study performed in 2019 found CBGA as activator peroxisome proliferator-activated receptors (PPARs). This receptor regulates metabolism, and malfunctioning of this may cause metabolic disorders such as diabetes and dyslipidemia. By activating this receptor, CBG may treat these conditions.
Colon Cancer: CBGA kills colon cancer cells and prevents the growth and proliferation of polyps. A study found that CBGA can also arrest the cancer cell cycle and hasten early cancer cell death
Will CBGA get you high?
CBGA is a non-psychoactive compound that doesn’t get you high.
What is the difference between CBG and CBGA?
CBG (cannabigerol) is regarded as the mother of all cannabinoids, while CBGA is the precursor of CBG. Although CBG is found in smaller quantities, i.e., only 1% in cannabis plants, it has significant importance due to its acidic form CBGA (cannabigerolic acid) which is the parent compound of all other cannabinoids.
The medical benefits of CBG and CBGA are almost similar.