Cannabigerol (CBG) and Cannabigerolic Acid (CBGA): medical benefits and research
What are CBG and CBGA?
Besides cannabidiol (CBD), one of the most popular forms of medical cannabis, another important compound CBG (cannabigerol), is regarded as the mother of all cannabinoids. Although CBG is found in smaller quantities, i.e., only 1% in cannabis plants, it has significant importance due to its acidic form CBGA (cannabigerolic acid), the parent compound of all other cannabinoids. Increasing research suggests that cannabigerol (CBG) has significant and unique health benefits.
How CBG and CBGA are made?
Young cannabis plants have cannabigerolic acid (CBGA), which undergoes enzymatic degradation and converts into three cannabinoids; tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). The resulting acidic forms of these cannabinoids produce THC and CBD by a decarboxylation reaction catalyzed by light or heat.
The uses of CBG and CBGA
Since ongoing research reveals new benefits of CBG and CBGA, the market size and potential use of these compounds have also continued to grow exponentially.
In our body, CBG is processed by the Endocannabinoid System (ECS), which regulates various functions and processes such as sleep, appetite, mood, memory, production, and fertility. Endocannabinoids bind the receptor and trigger a signaling cascade that performs the required action. Enzymes of ECS destroy these cannabinoids after the completion of targeted activity. When in the body, CBG imitates endocannabinoids and exhibits a wide array of health benefits.
Promotes pain relief
This significant health benefit has sparked a renewed interest in the pharmaceutical industry towards the molecular chemistry of CBG.
CBG powerfully targets transient receptor potential (TRP) channels, which are well-known to be linked to pain perception. By regulating pain perception, CBG can promote analgesia without making you high.
Protects the brain
Oxidative stress can damage both cells and the immune system and can lead to neurological conditions. By acting as a potent antioxidant and neutralizing oxidative stress, CBG can prevent the loss of brain cells and help to:
I. Support muscle function and movement in Huntington’s disease
II. Prevent immune cell overactivation that can worsen multiple sclerosis.
III. Support the recovery of nigrostriatal brain cells in Parkinson’s disease.
Supports the destruction of cancer cells
Oxidative stress can damage the immune system, cause early cell death, and activate cancer cells. By neutralizing oxidative stress, CBG can help promote the death of cancer cells.
Prevent bladder dysfunction
Recent research found five different endocannabinoids receptor on the bladder that takes part in bladder muscle contraction. The same study regarded CBG as a future tool in urology that can inhibit muscle contractions and helps prevent several bladder dysfunctions.
Lower Intraocular pressure
CBG bind endocannabinoid receptor in the eye where it reduces intraocular pressure by increasing aqueous humor outflow. The ability of CBG to reduce intra-ocular pressure culminates into its potential therapeutic use in glaucoma.
CBG may improve appetite by increasing how often hunger sets in, with minimal side effects
The benefits of investing in this industry and BioMedican
As the cannabinoid market surges, the therapeutic value of hundreds of cannabinoids is coming to light. It is their potential to impact the quality of life of many patients. Investors benefit from the ability to participate in an industry currently gaining enormous momentum. Our proprietary technology can revolutionize the cannabinoid supply chain and directly feed into several markets where cannabinoids and terpenes are in high demand. As the production of cannabinoids and terpenes through biosynthesis is significantly quicker than traditional methods, investors can expect a faster return on investments.
Which is better, CBD or CBG?
Though CBG, CBD, and THC are all derivatives of CBGA, only THC can cause the psychological effects of “getting high.” Both CBG and CBD are non-psychoactive.
However, the main difference between CBG and CBD is the health benefit profiles that each therapy offers. As mentioned before, CBG is known to increase appetite. In contrast, CBD reduces appetite and aid in weight loss.
A scientific aspect that differentiates CBG from CBD is how they work. CBG works directly on cannabinoid receptors within the brain, while CBD works indirectly on the endocannabinoid system within the brain. You may argue that CBG has a more powerful, direct effect than CBD.
Why Biomedican’s biosynthesis from yeast is the best way to produce CBG?
The production of CBG/CBGA through biosynthesis offers a way to reduce the environmental footprint, decrease production time, circumvent regulatory oversight, and produce high-quality cannabinoids. Biosynthesis, a process that has been used for several years in multiple industries, revolutionizes the production of cannabinoids by reducing the cost of their production by 70-90%.
Biomedican uses a unique proprietary yeast that undergoes the natural metabolic process of fermentation to produce CBG/CBGA identical to its counterparts in nature. The advantage of this natural process is that it is 100% pure, reliable, and does not come with the undesirable side effects of chemical synthesis.
What kind of business will need CBG and CBGA?
CBG/CBGA has entered various medicinal industries like pharmaceuticals and consumer industries like natural health, food, cosmetics, and nutraceuticals.
Consumers are generally moving towards bioidentical products as the movement to cut out harmful synthetic compounds and chemicals. Therefore, manufacturers also turn to biosynthetic CBG/CBGA to make healthier, safer products with additional benefits. The pharmaceutical industry has noted the benefits of cannabinoids, including high efficacy against many ailments with fewer side effects.
Problems with CBG production
CBG is considered one of the most “high-end” cannabinoids because it is difficult to acquire and has many health benefits. CBG is found as a minor cannabinoid in most cannabis plant strains. Therefore, plant strains with high CBG content are cultivated to get enough quantity of CBG. The amount of CBG is high in the young cannabis plant and decreases gradually with aging. Therefore, only young plants can be processed to get CBG/CBGA, present in a very minute quantity making their extraction and purification inefficient, costly, and environmentally taxing. Cultivation also requires significant regulatory oversight and can produce inconsistent yields prone to contamination from pests, mold, and pesticides.
Frequently asked questions:
Are CBG products legal?
CBG and CBGA are not listed in controlled substances. CBG and CBGA derived from hemp are federally legal under Farm Bill 2018. However. The legality of manufacturing, possession, and consumption of CBG and CBGA may vary from state to state. Till February 2021, 47 states allowed CBG. 15 states legalized the recreational and adult use of CBG. Despite legalization, all the CBG products are closely observed by FDA.
Can you take too much CBG?
A common saying is, “The difference between a good medicine and a poison is the dosage.”
Therefore, CBG must be taken in an appropriate amount to receive its desired therapeutic effects.
How is CBG made?
Young cannabis plants have cannabigerolic acid (CBGA). Cannabigerolic acid (CBGA) is an acidic form of CBG and precursor of all cannabinoids, including CBG. CBGA undergoes enzymatic degradation and converts into three cannabinoids; tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). The resulting acidic forms of these cannabinoids produce THC and CBD by a decarboxylation reaction catalyzed by light or heat.
Is cannabigerol(CBG) psychoactive?
Unlike THC, CBG is non-psychoactive, which means it will not get you “high.”
What are the side effects of CBG?
There is not enough information from scientific evidence to know if cannabigerol is safe and what the side effects it may have.
However, Too much intake of CBG may cause diarrhea.
What is CBG oil?
CBG oil is extracted from cannabinoid -cannabigerol (CBG). Pure CBG oil is rare but much more beneficial compared to other cannabinoids. CBG is utilized due to its fat-burning, pain alleviating, and mood-stabilizing properties. It is also used to maintain the sleep cycle.
What is CBG?
CBG, cannabigerol, is one of over 120 cannabinoids, which have been discovered within the Cannabis Sativa plant. Cannabigerol (CBG) is a well-known non-psychoactive compound known as the mother of all cannabinoids. It is present only 1% in cannabis plants.
What is CBGA good for?
There is limited medical research on CBGA. However, early studies have provided some suggestions about its potential applications.
Cardiovascular Disease: CBGA may help combat cardiovascular disease in diabetic patients. An in vitro study found CBGA as an inhibitor of enzyme aldose reductase. This enzyme leads to heart and other problems as a contributor of the oxidative stress.
Metabolic Disorders: CBGA may also treat patients with metabolic disorders. A simulation study performed in 2019 found CBGA as activator peroxisome proliferator-activated receptors (PPARs). This receptor regulates metabolism, and malfunctioning of this may cause metabolic disorders such as diabetes and dyslipidemia. By activating this receptor, CBG may treat these conditions.
Colon Cancer: CBGA kills colon cancer cells and prevents the growth and proliferation of polyps. A study found that CBGA can also arrest the cancer cell cycle and hasten early cancer cell death
What is CBG used for?
Use in cosmetics products: CBG is a vital skincare and cosmetics ingredient approved by the European Commission due to its antibacterial, anti-inflammatory, and antioxidant properties.
Veterinary use: Various preclinical studies highlighted the relaxing effect of CBG in animals without causing drowsiness. CBG holds a variety of health benefits for your canine friend.
Use in the food industry: Due to the history of safe consumption of CBG in humans, it is possible to use this cannabinoid in the food industry.
CBG also reduced the burden on the human healthcare system by positively impacting various ailments. A few of the many promising health/medical benefits of CBG include treatment of:
- Huntington’s Disease – In several models of Huntington’s Disease, treatment with CBG has been shown to reduce the loss of brain cells and improve motor function.
- Multiple Sclerosis (MS) – In models of MS, CBG has been shown to alleviate symptoms by preventing the overactivation of immune cells.
- Parkinson’s Disease – In Parkinson’s, cells in the nigrostriatal region of the brain are lost. Studies have indicated that CBG may help to both prevent the destruction of and augment the recovery of brain cells in this region.
- Colon Cancer – Studies have demonstrated that extracts containing CBG have properties that may kill colon cancer cells.
- Appetite Stimulation – CBG may improve appetite by increasing how often hunger sets in, with minimal side effects.
What is the difference between CBG and CBGA?
CBG (cannabigerol) is regarded as the mother of all cannabinoids, while CBGA is the precursor of CBG. Although CBG is found in smaller quantities, i.e., only 1% in cannabis plants, it has significant importance due to its acidic form CBGA (cannabigerolic acid) which is the parent compound of all other cannabinoids.
The medical benefits of CBG and CBGA are almost similar.
Will CBGA get you high?
CBGA is a non-psychoactive compound that doesn’t get you high.